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Publicacion

Titulo:	CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women
Autores:	GARCIA-MARTINEZ A GAMBOA-LOIRA B MARÍA ELIZABETH TEJERO BARRERA SIERRA-SANTOYO A CEBRIAN ME LOPEZ-CARRILLO L
Tipo de Licencia:	http://creativecommons.org/licenses/by/4.0
Fecha de Publicación:	1 de Septiembre de 2017
Resumen:	OBJECTIVE: To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women. MATERIALS AND METHODS: 952 incident cases with histologically confirmed BC were matched by age (+/- 5 years) and zone of residence with 998 healthy population controls. Genetic variants in genes CYP1A1, CYP1B1, GSTM1 and GSTT1were genotyped by allelic discrimination and multiplex PCR. In a subsample of women, 105 markers for ancestry were determined. RESULTS: An increased BC risk, independent of other BC risk factors, was observed among carriers of CYP1B1 G119T genotype (T/T vs. G/G: OR=1.9; 95%CI 1.4-2.5). CONCLUSION: Our results support the existence of genetic susceptibility for BC conferred by CYP1B1 G119T variant among Mexican women.
Editorial:	Salud Publica de Mexico
Idioma:	Ingles
Palabras Clave:	Adolescent Adult Africa/ethnology Aged Breast Neoplasms/epidemiology/genetics Case-Control Studies Cytochrome P-450 CYP1A1/genetics Cytochrome P-450 CYP1B1/genetics Ethnic Groups/genetics Europe/ethnology Female Genetic Predisposition to Disease Genotype Glutathione Transferase/genetics Humans INDEL Mutation Indians North American/genetics Mexico/epidemiology Middle Aged Multiplex Polymerase Chain Reaction Polymorphism Single Nucleotide Risk Young Adult
URL:	https://repositorio.inmegen.gob.mx/record/47

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