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Titulo:	Nopal feeding reduces adiposity, intestinal inflammation and shifts the cecal microbiota and metabolism in high-fat fed rats
Autores:	SOFÍA MORÁN RAMOS HE X CHIN EL TOVAR AR TORRES N SLUPSKY CM RAYBOULD HE
Tipo de Licencia:	http://creativecommons.org/licenses/by/4.0
Fecha de Publicación:	14 de Febrero de 2018
Resumen:	Nopal is a cactus plant widely consumed in Mexico that has been used in traditional medicine to aid in the treatment of type-2 diabetes. We previously showed that chronic consumption of dehydrated nopal ameliorated hepatic steatosis in obese (fa/fa) rats; however, description of the effects on other tissues is sparse. The aim of the present study was to investigate the effects of nopal cladode consumption on intestinal physiology, microbial community structure, adipose tissue, and serum biochemistry in diet-induced obese rats. Rats were fed either a normal fat (NF) diet or a HF diet containing 4% of dietary fiber from either nopal or cellulose for 6 weeks. Consumption of nopal counteracted HF-induced adiposity and adipocyte hypertrophy, and induced profound changes in intestinal physiology. Nopal consumption reduced biomarkers of intestinal inflammation (mRNA expression of IL-6) and oxidative stress (ROS), modfied gut microbiota composition, increasing microbial diversity and cecal fermentation (SCFA), and altered the serum metabolome. Interestingly, metabolomic analysis of dehydrated nopal revealed a high choline content, which appeared to generate high levels of serum betaine, that correlated negatively with hepatic triglyceride (TAG) levels. A parallel decrease in some of the taxa associated with the production of trimethylamine, suggest an increase in choline absorption and bioavailability with transformation to betaine. The latter may partially explain the previously observed effect of nopal on the development of hepatic steatosis. In conclusion, this study provides new evidence on the effects of nopal consumption on normal and HF-diet induced changes in the intestine, the liver and systemic metabolism.
Editorial:	PLoS One
Idioma:	Ingles
Palabras Clave:	Adiposity/drug effects Animal Feed Animals Blood Glucose/metabolism Cactaceae/chemistry Cecum/metabolism/microbiology Diet High-Fat Dietary Fiber/administration & dosage Gastrointestinal Microbiome/drug effects/physiology Gene Expression/drug effects Inflammation/genetics/prevention & control Interleukin-6/genetics/metabolism Intestines/drug effects/metabolism/pathology Liver/drug effects/metabolism Magnetic Resonance Spectroscopy Male Metabolomics/methods Plant Preparations/administration & dosage/pharmacology Rats Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Triglycerides/blood/metabolism
URL:	https://repositorio.inmegen.gob.mx/record/103

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