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Titulo:	Analysis of shared heritability in common disorders of the brain
Autores:	ANTTILA V BULIK-SULLIVAN B FINUCANE HK WALTERS RK BRAS J DUNCAN L ESCOTT-PRICE V FALCONE GJ GORMLEY P MALIK R PATSOPOULOS NA RIPKE S WEI Z YU D LEE PH TURLEY P GRENIER-BOLEY B CHOURAKI V KAMATANI Y BERR C LETENNEUR L HANNEQUIN D AMOUYEL P BOLAND A DELEUZE JF DURON E VARDARAJAN BN REITZ C GOATE AM HUENTELMAN MJ KAMBOH MI LARSON EB ROGAEVA E ST GEORGE-HYSLOP P HAKONARSON H KUKULL WA FARRER LA BARNES LL BEACH TG DEMIRCI FY HEAD E HULETTE CM JICHA GA KAUWE JSK KAYE JA LEVERENZ JB LEVEY AI LIEBERMAN AP PANKRATZ VS POON WW QUINN JF SAYKIN AJ SCHNEIDER LS SMITH AG SONNEN JA STERN RA VAN DEERLIN VM VAN ELDIK LJ HAROLD D RUSSO G RUBINSZTEIN DC BAYER A TSOLAKI M PROITSI P FOX NC HAMPEL H OWEN MJ MEAD S PASSMORE P MORGAN K NOTHEN MM ROSSOR M LUPTON MK HOFFMANN P KORNHUBER J LAWLOR B MCQUILLIN A AL-CHALABI A BIS JC RUIZ A BOADA M SESHADRI S BEISER A RICE K VAN DER LEE SJ DE JAGER PL GESCHWIND DH RIEMENSCHNEIDER M RIEDEL-HELLER S ROTTER JI RANSMAYR G HYMAN BT CRUCHAGA C ALEGRET M WINSVOLD B PALTA P FARH KH CUENCA-LEON E FURLOTTE N KURTH T LIGTHART L TERWINDT GM FREILINGER T RAN C GORDON SD BORCK G ADAMS HHH LEHTIMAKI T WEDENOJA J BURING JE SCHURKS M HRAFNSDOTTIR M HOTTENGA JJ PENNINX B ARTTO V KAUNISTO M VEPSALAINEN S MARTIN NG MONTGOMERY GW KURKI MI HAMALAINEN E HUANG H HUANG J SANDOR C WEBBER C MULLER-MYHSOK B SCHREIBER S SALOMAA V LOEHRER E GOBEL H MACAYA A POZO-ROSICH P HANSEN T WERGE T KAPRIO J METSPALU A KUBISCH C FERRARI MD BELIN AC VAN DEN MAAGDENBERG AMJM ZWART JA BOOMSMA D ERIKSSON N OLESEN J CHASMAN DI NYHOLT DR AVBERSEK A BAUM L BERKOVIC S BRADFIELD J BUONO R CATARINO CB COSSETTE P DE JONGHE P DEPONDT C DLUGOS D FERRARO TN FRENCH J HJALGRIM H JAMNADAS-KHODA J KALVIAINEN R KUNZ WS LERCHE H LEU C LINDHOUT D LO W LOWENSTEIN D MCCORMACK M MOLLER RS MOLLOY A NG PW OLIVER K PRIVITERA M RADTKE R RUPPERT AK SANDER T SCHACHTER S SCHANKIN C SCHEFFER I SCHOCH S SISODIYA SM SMITH P SPERLING M STRIANO P SURGES R THOMAS GN VISSCHER F WHELAN CD ZARA F HEINZEN EL MARSON A BECKER F STROINK H ZIMPRICH F GASSER T GIBBS R HEUTINK P MARTINEZ M MORRIS HR SHARMA M RYTEN M MOK KY PULIT S BEVAN S HOLLIDAY E ATTIA J BATTEY T BONCORAGLIO G THIJS V CHEN WM MITCHELL B ROTHWELL P SHARMA P SUDLOW C VICENTE A MARKUS H KOURKOULIS C PERA J RAFFELD M SILLIMAN S BORASKA PERICA V THORNTON LM HUCKINS LM WILLIAM RAYNER N LEWIS CM GRATACOS M RYBAKOWSKI F KESKI-RAHKONEN A RAEVUORI A HUDSON JI REICHBORN-KJENNERUD T MONTELEONE P KARWAUTZ A MANNIK K BAKER JH O'TOOLE JK TRACE SE DAVIS OSP HELDER SG EHRLICH S HERPERTZ-DAHLMANN B DANNER UN VAN ELBURG AA CLEMENTI M FORZAN M DOCAMPO E LISSOWSKA J HAUSER J TORTORELLA A MAJ M GONIDAKIS F TZIOUVAS K PAPEZOVA H YILMAZ Z WAGNER G COHEN-WOODS S HERMS S JULIA A RABIONET R DICK DM RIPATTI S ANDREASSEN OA ESPESETH T LUNDERVOLD AJ STEEN VM PINTO D SCHERER SW ASCHAUER H SCHOSSER A ALFREDSSON L PADYUKOV L HALMI KA MITCHELL J STROBER M BERGEN AW KAYE W SZATKIEWICZ JP CORMAND B RAMOS-QUIROGA JA SANCHEZ-MORA C RIBASES M CASAS M HERVAS A ARRANZ MJ HAAVIK J ZAYATS T JOHANSSON S WILLIAMS N DEMPFLE A ROTHENBERGER A KUNTSI J OADES RD BANASCHEWSKI T FRANKE B BUITELAAR JK ARIAS VASQUEZ A DOYLE AE REIF A LESCH KP FREITAG C RIVERO O PALMASON H ROMANOS M LANGLEY K RIETSCHEL M WITT SH DALSGAARD S BORGLUM AD WALDMAN I WILMOT B MOLLY N BAU CHD CROSBIE J SCHACHAR R LOO SK MCGOUGH JJ GREVET EH MEDLAND SE ROBINSON E WEISS LA BACCHELLI E BAILEY A BAL V BATTAGLIA A BETANCUR C BOLTON P CANTOR R CELESTINO-SOPER P DAWSON G DE RUBEIS S DUQUE F GREEN A KLAUCK SM LEBOYER M LEVITT P MAESTRINI E MANE S DE-LUCA DM PARR J REGAN R REICHENBERG A SANDIN S VORSTMAN J WASSINK T WIJSMAN E COOK E SANTANGELO S DELORME R ROGE B MAGALHAES T ARKING D SCHULZE TG THOMPSON RC STROHMAIER J MATTHEWS K MELLE I MORRIS D BLACKWOOD D MCINTOSH A BERGEN SE SCHALLING M JAMAIN S MAASER A FISCHER SB REINBOLD CS FULLERTON JM GUZMAN-PARRA J MAYORAL F SCHOFIELD PR CICHON S MUHLEISEN TW DEGENHARDT F SCHUMACHER J BAUER M MITCHELL PB GERSHON ES RICE J POTASH JB ZANDI PP CRADDOCK N FERRIER IN ALDA M ROULEAU GA TURECKI G OPHOFF R PATO C ANJORIN A STAHL E LEBER M CZERSKI PM CRUCEANU C JONES IR POSTHUMA D ANDLAUER TFM FORSTNER AJ STREIT F BAUNE BT AIR T SINNAMON G WRAY NR MACINTYRE DJ PORTEOUS D HOMUTH G RIVERA M GROVE J MIDDELDORP CM HICKIE I PERGADIA M MEHTA D SMIT JH JANSEN R DE GEUS E DUNN E LI QS NAUCK M SCHOEVERS RA BEEKMAN AT KNOWLES JA VIKTORIN A ARNOLD P BARR CL BEDOYA-BERRIO G BIENVENU OJ BRENTANI H BURTON C CAMARENA B CAPPI C CATH D CAVALLINI M CUSI D DARROW S DENYS D DERKS EM DIETRICH A FERNANDEZ T FIGEE M FREIMER N GERBER G GRADOS M GREENBERG E HANNA GL HARTMANN A HIRSCHTRITT ME HOEKSTRA PJ HUANG A HUYSER C ILLMANN C JENIKE M KUPERMAN S LEVENTHAL B LOCHNER C LYON GJ MACCIARDI F MADRUGA-GARRIDO M MALATY IA MARAS A MCGRATH L MIGUEL EC MIR P NESTADT G JOSÉ HUMBERTO NICOLINI SÁNCHEZ OKUN MS PAKSTIS A PASCHOU P PIACENTINI J PITTENGER C PLESSEN K RAMENSKY V RAMOS EM REUS V RICHTER MA RIDDLE MA ROBERTSON MM ROESSNER V ROSARIO M SAMUELS JF SANDOR P STEIN DJ TSETSOS F VAN NIEUWERBURGH F WEATHERALL S WENDLAND JR WOLANCZYK T WORBE Y ZAI G GOES FS MCLAUGHLIN N NESTADT PS GRABE HJ DEPIENNE C KONKASHBAEV A LANZAGORTA N VALENCIA-DUARTE A BRAMON E BUCCOLA N CAHN W CAIRNS M CHONG SA COHEN D CRESPO-FACORRO B CROWLEY J DAVIDSON M DELISI L DINAN T DONOHOE G DRAPEAU E DUAN J HAAN L HOUGAARD D KARACHANAK-YANKOVA S KHRUNIN A KLOVINS J KUCINSKAS V LEE CHEE KEONG J LIMBORSKA S LOUGHLAND C LONNQVIST J MAHER B MATTHEISEN M MCDONALD C MURPHY KC NENADIC I VAN OS J PANTELIS C PATO M PETRYSHEN T QUESTED D ROUSSOS P SANDERS AR SCHALL U SCHWAB SG SIM K SO HC STOGMANN E SUBRAMANIAM M TONCHEVA D WADDINGTON J WALTERS J WEISER M CHENG W CLONINGER R CURTIS D GEJMAN PV HENSKENS F MATTINGSDAL M OH SY SCOTT R WEBB B BREEN G CHURCHHOUSE C BULIK CM DALY M DICHGANS M FARAONE SV GUERREIRO R HOLMANS P KENDLER KS KOELEMAN B MATHEWS CA PRICE A SCHARF J SKLAR P WILLIAMS J WOOD NW COTSAPAS C PALOTIE A SMOLLER JW SULLIVAN P ROSAND J CORVIN A NEALE BM
Tipo de Licencia:	http://creativecommons.org/about/cc0/
Fecha de Publicación:	22 de Junio de 2018
Resumen:	Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Editorial:	SCIENCE
Idioma:	Ingles
Palabras Clave:
URL:	https://repositorio.inmegen.gob.mx/record/447

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